Hello David,
The issues you're experiencing stem from outdated system components, permission problems, or difficulties with the Microsoft AutoUpdate tool. Ensure that your Mac fulfills the system requirements for Microsoft 365 and that your macOS is fully updated. After that, download and install the most recent version of Microsoft AutoUpdate via this official link: Download Microsoft AutoUpdate for Mac.
If you continue to face issues, you can refer to this comprehensive troubleshooting guide from Microsoft, Troubleshoot Microsoft AutoUpdate in Office for Mac.
Additionally, verify that you have sufficient disk space and a reliable internet connection, and consider running the installer from your desktop rather than from cloud storage services like Dropbox or Google Drive.