Hi @Austin,
Thank you for posing your question in the Microsoft Q&A forum.
Based on your sharing, since you can only open Excel in safe mode and the issue persist even after reinstalling Office, the issue is highly due to an issue with Excel add-ins because in Safe mode add-ins are disabled.
The previous response by Q&A Assist does provide some troubleshooting steps and I suggest you can try them to see if it helps. The guideline I provide below will have some steps as same as the previous reply so you can skip them if it does not resolve your issue:
1- Disable add-in
- Go to File > Options > Add-ins > select Excel Add-ins > Go > uncheck all listed add-ins and click OK
- Repeat the above step but change Excel Add-ins to COM Add-ins
- Restart Excel and check if the error is gone. Then re-enable the add-ins one by one and restarting Excel each time to find which one causing the error.
2- Delete Book.xltx in XLSTART folder
- Open File Explorer and navigate to this path C:\Users<YourUserName>\AppData\Roaming\Microsoft\Excel\XLSTART
- If you see Book.xltx or Sheet.xltx folder in there, delete it.
- Restart your computer and open Excel again to see if the issue persists
3- Reset Excel default settings
- Press Windows + R and type regedit then OK
- In the bar, paste this address to navigate to the correct path: HKEY_CURRENT_USER\Software\Microsoft\Office\16.0\Excel
- Right-click the Excel key and press Delete. After that restart Excel to see if the issue persists.
I hope this information is helpful. Please follow these steps and let me know if it works for you. If not, we can work together to resolve this.
Thank you for your patience and your understanding. If you have any questions or need further assistance, please feel free to share them in the comments so I can continue to support you.
I look forward to hearing from you.
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